Immunological correlation between morphine tolerance and the effect of naloxone in rats of different age |
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Authors: | L V Kalyuzhnyi M A Gruden' S V Litvinova G V Torgovanova E A Shumova |
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Institution: | (1) P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow |
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Abstract: | In 3–6-week-old morphine-sensitive rats, in which morphine injection produced an analgetic effect, the serum titer of antimorphine
antibodies 24 h postinjection is less than half that observed in morphine-resistant animals. Administration of naloxone to
morphine-sensitive rats induces hyperalgesia and considerably raises the serum titer of antimorphine antibodies. Chronic injections
of the same dose of morphine, which cause its analgetic effect to disappear, increase the titer of antibodies in morphine-sensitive
rats 2-fold. In morphine-resistant rats naloxone produces an analgetic effect followed by its gradual decay and disappearance
in the course of chronic administration. Subsequent administration of morphine induces analgesia, raises the titer of antimorphine
antibodies, and lowers the titer of antiidiotypic antibodies.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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1, pp. 67–70, January, 1996
Presented by K. V. Sudakov, Member of the Russian Academy of Medical Sciences |
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Keywords: | morphine tolerance naloxone antimorphine antibodies antiidiotypes |
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