| 大鼠急性脑梗死溶栓治疗时间窗的研究 |
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| 引用本文： | 常丽英,张新江,张苏明,易黎,方思羽,殷小平.大鼠急性脑梗死溶栓治疗时间窗的研究[J].卒中与神经疾病,2002,9(3):140-143. |
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| 作者姓名： | 常丽英 张新江 张苏明 易黎 方思羽 殷小平 |
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| 作者单位： | 1. 湖北省襄樊市中心医院神经内科
2. 430030,武汉,华中科技大学同济医学院附属同济医院神经内科 |
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| 基金项目： | 国家自然科学基金资助项目(No.30070825) |
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| 摘 要： | 目的 研究尿激酶溶栓治疗大鼠急性脑梗死的时间窗。方法 用自体血栓法制作大鼠大脑中动脉闭塞 (MCAO)模型 ,在栓塞后 30、6 0、90、12 0、180min(A、B、C、D、E组 )经静脉注射尿激酶 (5万U/kg)溶栓 ,用神经功能缺损评分、TTC染色测梗死体积、核磁共振 (MRI)及病理学观察 ,比较不同时间点溶栓的疗效及安全性。结果 MCAO后 90min内溶栓 (A、B、C组 )能显著改善神经功能 ,缩小梗死体积 (P <0 .0 5 ) ,12 0min以后溶栓组 (D、E组 )与对照组无显著性差异 (P >0 .0 5 ) ,且并发脑出血率高 (31.3% )。结论 本研究提示大鼠脑梗死溶栓治疗最佳时间窗为栓塞后 90min内 ,溶栓治疗时间越早 ,疗效及安全性越高。
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| 关 键 词： | 大脑中动脉 脑梗死 血栓溶解 尿激酶 |
| 文章编号： | 1007-0478(2002)03-0140-04 |
Therapeutic window of thrombolysis with urokinase in acute cerebral infarction in rats |
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| Chang Liying,Zhang Xinjiang,Zhang Suming,et al..Therapeutic window of thrombolysis with urokinase in acute cerebral infarction in rats[J].Stroke and Nervous Diseases,2002,9(3):140-143. |
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| Authors: | Chang Liying Zhang Xinjiang Zhang Suming |
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| Institution: | Chang Liying,Zhang Xinjiang,Zhang Suming,et al. Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong Science and Technology University,Wuhan 430030 |
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| Abstract: | Objective To investigate the time window of urokinase(UK) thrombolysis.Methods The middle cerebral artery occlusion(MCAO) model was induced in rats by autologous clot, the UK (50000 U/kg) was injected intravenously at 30th (group A)\,60th(B)\,90th(C)\,120th(D)\,180th(E) minute after MCAO respectively. The efficacy and safety of UK were evaluated by neurologic deficit score, infarct volume and magnetic resonance imaging (MRI).Results Both neurologic deficit score and infarct volume were significantly improved by injected UK within 90 minutes after MCAO( P < 0.05 ). The infarct size didn't reduce, however, the rate of cerebral hemorrhage increased ( 31.3% ) when treated by UK at 120th or 180th minute.Conclusion Our study indicated that optimal therapeutic window of UK thrombolysis in acute infarct of rats is less than 90 minites after thrombosis. |
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| Keywords: | Middle cerebral artery Cerebral infarction Thrombolysis Urokinase |
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