|
|||||
|
|
The role of apoptosis in preterm premature rupture of the human fetal membranes |
|
| Authors: | Aylin Saglam Cinar Ozgur Iris Derwig Bekir Serdar Unlu Funda Gode Tamer Mungan |
| Institution: | 1. Perinatology Department, Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara, Turkey 2. Department of Histology-Embryology, School of Medicine, Ankara University, 06100, Sihhiye, Ankara, Turkey 3. King’s College Hospital, London, UK 4. Department of Obstetrics and Gynecology, Rize State Hospital, 53000, Rize, Turkey 5. Department of Obstetrics and Gynecology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey |
| Abstract: | PurposeThe present study was designed to examine apoptotic cell death via the caspase-dependent pathway in human fetal membranes.MethodsAmniotic membrane samples were collected from three groups of women: group 1, women with preterm premature rupture of fetal membranes (PPROM) after cesarean delivery (n = 10), group 2, women with preterm labor (PTL) with intact membranes after cesarean delivery (n = 9) and group 3, women with term labor and vaginal delivery after an uncomplicated pregnancy (controls) (n = 11).ResultsActive caspase-3 immunopositivity (ACPI) of the PPROM group was significantly higher than that of the control group (p < 0.05). ACPI was higher in the PTL with intact membranes group as compared to the control group; however, it did not reach statistical significance (p > 0.05).ConclusionActive caspase-3 positivity is increased in the fetal membranes of those women with PPROM. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |