阿托伐他汀辅助治疗老年单纯收缩期高血压的疗效观察及对动脉弹性的影响

目的探讨阿托伐他汀在老年单纯性收缩期高血压治疗中的临床疗效及对动脉弹性的影响。方法将我院收治的177例老年单纯收缩期高血压患者按照分层随机分组法分为四组,A1组和A2组为联合用药组,两组均给予阿托伐他汀+氨氯地平,B1组和B2组为单独用药组,两组均给予氨氯地平,A1和B1组年龄在60~75岁,A2和B2组年龄在75岁以上,观察四组患者的临床疗效及动脉弹性指数。结果联合用药组SBP达标率、脉压差(PP)、动脉弹性指数及血管内皮功能改善情况显著优于单独用药组,两组间差异有统计学意义(P<0.05);A1组SBP达标率、PP、动脉弹性指数及血管内皮功能改善情况显著优于A2组,B1组以上观察指标也显著优于B2组,不同年龄患者组间差异有统计学意义(P<0.05)。结论阿托伐他汀能显著提高临床疗效和改善动脉弹性,不同年龄段患者临床获益率不同,年龄越小获益率越大。

The Clinical Efficacy of Atorvastatin in the Adjuvant Treatment of Elderly Patients with Isolated Systolic Hypertension and the Role of Arterial Elasticity

Objective To explore the clinical efficacy of atorvastatin in the adjuvant treatment of elderly patients with isolated systolic hypertension and the role of arterial elasticity. Methods According to a stratified randomization method, 177 cases of elderly patients with isolated systolic hypertension were divided into the observation group and the control group in our hospital, A1 and A2 groups were given atorvastatin ＋ amlodipine,B1 and B2 group were given amlodipine, A1 and B1 group aged between 60-75 years of age, A2 and B2 group of patients aged 75 years or more, the clinical efficacy and the arterial elasticity index of four groups were observed. Results The combined treatment group was significantly better than the single drug group in the SBP compliance rate, PP, arterial elasticity index and vascular endothelial fimction, the difference between the two groups was significant（P〈0.05）; A1 group was significantly better than A2 group in the SBP compliance rate. PP. arterial elasticity index and vascular endothelial function, B 1 group also was significantly better than B2 group in the above observations indicators, the difference between the different age groups was significant（P〈0.05）. Conelusiun Atorvastatin can significantly improve the clinical efficacy and improve arterial elasticity, the clinical benefit rate of the different age groups was different, the clinical benefit rate of young patients was higher.