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Suppression of experimental allergic encephalomyelitis after dietary zinc deprivation in guinea pigs |
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| Authors: | R. Scelsi D.M. Franciotta C. Camana F. Savoldi M. Allegrini |
| Affiliation: | 1Sezione di Anatomia Patologica, University of Pavia 27100 Pavia, Italy 2Clinica Neurologica “C. Mondino” IRCCS, University of Pavia 27100 Pavia, Italy 3Istituto di Scienze Sanitarie Applicate, University of Pavia 27100 Pavia, Italy 4Dipartimento di Patologia Umana ed Ereditaria, University of Pavia 27100 Pavia, Italy |
| Abstract: | The effects of different levels of zinc (Zn) in the diet were tested in the animal model of acute experimental allergic encephalomyelitis (EAE), which is considered a prototype for cell-mediated autoimmune disease of the central nervous system (CNS). Acute EAE was induced in guinea pigs maintained with normal, high and low levels of Zn in the diet. The animals fed normal and Zn-supplemented diets showed the same survival rates; the incidence and severity of the disease was similar for both groups. Zn-deficient animals exhibited the expected symptoms of Zn deficiency and after sensitization did not develop neurological signs of EAE; some of them presented only focal inflammatory alteration in CNS. |
| Keywords: | Zinc deficiency experimental allergic encephalomyelitis immunomodulation Guinea pigs |
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