uPA与uPAR在肾细胞癌中的表达及其意义

①目的 探讨尿酸氧化酶(uPA)、尿酸氧化酶受体(uPAR)在肾细胞癌中的表达特征及其在肾癌恶性生长中的作用。②方法 选取40例不同分化程度及临床分期的肾细胞癌组织和10例正常肾组织，采用Supervision法进行免疫组织化学染色，检测uPA、uPAR的表达。③结果 uPA、uPAR的表达程度与肾癌细胞分化程度及临床分期有关，分化越差、临床分期越晚，则表达程度越高。在肿瘤细胞增殖密集区域，uPA、uPAR阳性的肿瘤细胞比例较低，而在肿瘤细胞生长稀疏、肿瘤血管增殖旺盛的区域，阳性细胞比例较高。正常肾组织未见uPA、uPAR的表达。④结论 uPA、uPAR的表达是浸润性生长的肾细胞癌的特征之一，其表达程度可作为判断肾癌浸润性的重要参考指标之一。uPA、uPAR的表达对肾细胞癌血管发生可能起重要作用。

THE EXPRESSION OF uPA AND uPAR IN RENAL CARCINOMA

Objective To study the patterns of expression of urokinase (uPA) and urokinase receptor (uPAR) in human renal carcinoma. Methods The tissue of 40 cases of different stage and different differentiation renal cell carcinoma and 10 cases of normal kidney were taken for the study. The Supervision immunoperoxidase technique was used for staining. Results The intensity of the expressions of uPA and uPAR was correlated with the grade of tumour cell and clinical stage. The lower differentiation and later clinical stage, the higher the expressions would be. The expressions of uPA and uPAR were lower in densely proliferated areas and higher in areas of rich vascular proliferation. No expressions of uPA and uPAR were noted in normal renal tissues. Conclusion The expression of uPA or uPAR is one of the features of invasive renal carcinoma. The degree of the expression may be used as an important parameter for judgement of its severity. The combined expression of uPA and uPAR may play an important role in the angiogenesis of renal carcinoma.