Prophylactic and corrective action of the polyethylene oxide polyox WSR-301 in rats with experimental lipoidosis |
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Authors: | I A Sokolova A A Shakhnazarov S N Sergeev D V Davydov V S Baranov |
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Institution: | (1) Institute of Mechanics, Moscow State University, Moscow, USSR;(2) Institute of Oceanology, Russian Academy of Sciences, Moscow, USSR |
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Abstract: | Two once-weekly intravenous injections of the polyethylene oxide Polyox WSR-301 (yielding a blood concentration of the order
of 5×10−6 g/ml) led to a 38% decrease in the area occupied by sudanophilic lesions in the aortic arch of rats fed an atherogenic diet
for two weeks. Perfusion under constant pressure of the formalin-fixed vascular system in the posterior part of the body with
physiological saline and then with polyethylene oxide (10−5 g/ml) was without effect in normal rats and in those with mild lipoidosis, but reduced hydrodynamic vascular resistance by
9–14.5% in rats with pronounced lipoidosis. Intravenous injection of polyethylene oxide into anesthetized rats with pronounced
lipoidosis in doses that were subthreshold for normal rats (blood concentrations of the polymer were of the order of 10−7 g/ml) caused a 20% decrease in the total peripheral resistance to blood flow, with a 17–20% rise of the blood flow rate in
the carotid artery.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
6, pp. 587–589, June, 1995
Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences |
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Keywords: | atherosclerosis polyethylene oxide hemodynamics |
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