| 脂肪乳剂Intralipid对急性肺损伤兔前列腺素代谢及其肺功能的影响 |
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| 引用本文： | 秦环龙,吴肇汉. 脂肪乳剂Intralipid对急性肺损伤兔前列腺素代谢及其肺功能的影响[J]. 肠外与肠内营养, 1997, 0(2) |
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| 作者姓名： | 秦环龙 吴肇汉 |
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| 作者单位： | 上海医科大学中山医院外科!上海200032 |
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| 摘 要： | 为研究脂肪乳剂对急性肺损伤兔前列腺素代谢的影响 ,我们对实验动物予以肠外营养 ,持续静脉输注脂肪乳剂 4 8h。结果糖脂组血中及支气管肺泡灌洗液中血管紧张素转化酶( ACE)、超氧化物岐化酶 ( SOD)含量明显下降 ( P<0 .0 1) ,前列环素 ( PGI2 )、血栓素 ( TXA2 )及其PGI2 / TXA2 比值有明显升高 ( P<0 .0 1) ,灌洗液 ( BAL F)中细胞计数糖脂组明显下降 ( P<0 .0 1)。结果提示 ,脂肪乳剂可能通过调节前列腺素的合成 ,抑制中性粒细胞在肺内聚集及炎症反应 ,减轻了对肺的损伤
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| 关 键 词： | 脂肪乳剂 急性肺损伤 前列腺素 |
Effects of intralipid on prostaglandins metabilism of the acute lung injury |
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| Qin Huanlong,Wu Zhaohan. Effects of intralipid on prostaglandins metabilism of the acute lung injury[J]. Parenteral & Enteral Nutrition, 1997, 0(2) |
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| Authors: | Qin Huanlong Wu Zhaohan |
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| Affiliation: | Qin Huanlong,Wu Zhaohan Department of Surgery,Zhongshan H ospi- tal,Shanghai Medical University |
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| Abstract: | An animal model of acute lung injury induced by endotoxin was estabol- ished in rabbits.Parenteral nutrition solu- tions containing Intralipid was continuously infused48hours.The results suggested that the contents of SOD and ACE in serum and BALF significantly decreased,PGI2 and PGI2 /TXA2 markedly increased,and the number of PMNs in BALF significantly de- creased as compared with other groups.The results showed that Intralipid may be bene- ficial to the lung via alteration of prostaglandins by anti- aggressive of PMNs and anti- inflammation response. |
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| Keywords: | Intralipid Acute lung injury Prostaglandins |
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