mTOR信号通路与胃癌的研究进展

哺乳动物雷帕霉素靶蛋白（mTOR）及其信号通路调控蛋白质的合成,细胞生长、迁移、凋亡以及血管形成等,该信号通路在胃癌中常被高度激活,并与胃癌的复发、转移等临床病理特性密切相关。雷帕霉素及其衍生物通过阻断mTOR通路的信号传递,抑制胃癌细胞生长,促进肿瘤坏死,并与其他化疗药物产生协同作用,有望为胃癌预防和治疗提供有效的方法。

Progression of mTOR and Its Signaling Pathway in Gastric Cancer

Mammalian target of rapamycin（mTOR） and its signaling pathway regulate the protein synthesis,cellular growth,metabolism,apoptosis and angiogenesis. In gastric cancer,it was usually activated and intimately related to the clinical and pathological characteristics.Blocking the mTOR signaling pathway by rapamycin and its derivatives can lead to the inhibition of gastric cancer cells and promotion of tumor necrosis. Moreover,significant synergism was also observed in the combination of rapamycin with other chemotherapeutics. As a result,blocking the mTOR signaling pathway by rapamycin and its derivatives is expected to provide effective methods for the prevention and treatment of gastric cancer.