局灶性脑缺血大鼠康复训练干预时间的研究

目的研究康复训练不同干预时间对脑缺血大鼠神经恢复的影响。方法成年雄性SD大鼠(n=18),随机分成早运动组、晚运动组、静止组(每组n=6)。采用ZeaLonga法制备大脑中动脉梗死(MCAO)模型,早运动组和晚运动组分别在造模后24h和1周给予电动跑台训练,每天30min,持续1周。采用神经行为学评分、脑梗死体积评价神经功能恢复情况。结果在第2周末时,早运动组的神经行为学评分高于静止组,早运动组的脑梗死体积显著小于静止组(P<0.001),而晚运动组与静止组相比则均无此差异。结论早运动训练可能有助于脑缺血大鼠神经功能的恢复。

The study of the optimal time for exercise therapeutic intervention on rats with middle cerebral artery occlusion

Objects The purpose of this study was to investigate the effects of early and late treadmill training after occlusion of the middle cerebral arteryand the optimal time window for therapeutic intervention.Methods Eighteen male Sprague-Dawley rats were subjected to 60 min right middle cerebral artery occlusion(MCAO).All rats were randomly assigned to one of three groups:early training group(training started at 24 h post MCAO),late training group(training started at 1 week post MCAO),no-training group.A neurological evaluation scale was used to assess the neurological status of rats.Infarct volume was measured morphometrically.Results Early treadmill training was found to have significant effects in reducing brain infarct volume and in improving neurologic function when compared with spontaneous recovery.However,the same effects cannot be found in late training.Conclusions Based on the present findings,we would encourage early treadmill training for ischemic brain recovery.