特异性免疫治疗母婴传播所致慢性乙型肝炎23例

目的:观察特异性免疫疗法对母婴传播所致慢性乙型肝炎的疗效．方法:母婴传播的慢乙肝患者23例每月1次注射乙肝表面抗原负载的树突状细胞106,乙肝免疫球蛋白200 U．6次为1疗程,共2个疗程．疗程结束后6,12mo复查肝功能,乙肝标志, HBV-DNA定量(PCR法)．结果:在HBeAg阳性慢乙肝9例中有1例治疗后显示完全应答,7例显示部分应答．HBeAg 阴性慢乙肝4例中有2例出现部分应答．HBV 携带者5例未见应答．非活动性HBsAg携带者5 例中有1例显示完全应答,其余4例未应答．结论:特异性免疫疗法对母婴传播所致慢乙肝有一定疗效．

Potential effect of specific immunotherapy on chronic hepatitis B of vertical maternal-fetal transmission: an analysis of 23 cases

AIM: To study the efficacy of specific immunotherapy in the treatment of patients with chronic hepatitis B(CHB) of vertical maternal-fetal transmission. METHODS: HBsAg vaccine-loaded dendritic cells (DC, 106) and HBIg (200 U) were injected respectively into 23 patients with CHB of vertical transmission. Six months were considered as one course, and there were two courses in total. At the end of treatment,liver function, HBV DNA level and HBV markers in the patients were measured. RESULTS: Of the 9 patients with HBeAg( ) CHB, 1 case showed a complete response, and 7 showed partial responses. Of the 4 patients with HBeAg(-) CHB, partial responses occurred in 2 cases. No responses were observed in the 5 chronic HBV carriers. Of the 5 inactive HBsAg carriers, 1 case showed a complete response, while the rest showed no responses. CONCLUSION: The specific immunotherapy is effective in the treatment of CHB transmitted from the mothers.