Eudesmanolides from Taraxacum mongolicum and their inhibitory effects on the production of nitric oxide |
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| Authors: | Young-Hee Kim Soo-Jin Choo In-Ja Ryoo Jong-Seok Ahn Ick-Dong Yoo |
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| Affiliation: | (1) Biology Department, University of Washington, Seattle, WA 98195-5325, USA;(2) Western Fisheries Research Center (WFRC), US Geological Survey, Seattle, WA 98115, USA;(3) School of Biological Sciences, Seoul National University, Seoul, 151-742, Korea; |
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| Abstract: | A new eudesmanolide, 1β,3β-dihydroxy-eudesman-11(13)-en-6α,12-olide (1) was isolated and identified from Taraxacum mongolicum, together with two known compounds, 1β,3β-dihydroxyeudesman-6α,12-olide (2) and loliolide (3). The structure of 1 was established by analysis of its physical and spectroscopic data. 1 was found to have an inhibitory activity on nitric oxide production with an IC50 of 38.9 μM in activated RAW 264.7 cells. |
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