Discovery of an orally available PAR-1 antagonist as a novel antiplatelet agent |
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Authors: | Sunkyung Lee |
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Affiliation: | (1) Department of Head and Neck Surgery, Federation of Otolaryngology, La Timone University Hospital Center, 264, rue Saint-Pierre, 13385 Marseille Cedex 05, France |
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Abstract: | Antiplatelet therapy is a key treatment in atherothrombotic disease and platelet is activated via multiple pathways. Current agents do not interfere with all pathways including the protease-activated receptor-1 (PAR-1) pathway stimulated by thrombin. New antiplatelet agents targeting PAR-1 are aimed to reduce thrombosis ideally without increasing bleeding risk. This article provides a review of the new class of agents, PAR-1 antagonists. |
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