Effect of the derivatives of andrographolide on the morphology of <Emphasis Type="Italic">Bacillus subtilis</Emphasis> |
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Authors: | Chantana Aromdee Nongluksna Sriubolmas Suthep Wiyakrutta Supawadee Suebsasna Watcharee Khunkitti |
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Institution: | (1) Biotechnology Department, Chaitanya Bharathi Institute of Technology, Hyderabad, India;(2) Center for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Andhra Pradesh, 500 085, India |
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Abstract: | Andrographis paniculata has been reported to have antiviral, antipyretic and anticancer activities. Andrographolide, an ent-labdane diterpene, is an active constituent in this plant. In this study, andrographolide (1) and its natural derivative
14-deoxy-11,12-didehydroandrographolide (2) and 5 other semisynthetic derivatives were tested for their activity against Grampositive
and Gram-negative bacteria and Candida albicans. Only derivatives bearing a 14-acetyl group showed activity, and this activity was only against Gram-positive bacteria.
14-Acetylandrographolide showed the highest potency against Bacillus subtilis; the other 14-acetylandrographolides with additional substitution at the 3- and 19-hydroxyl groups showed lower activity
against Gram-positive bacteria. The morphology of B. subtilis after being treated with 14-acetylandrographolide was investigated with TEM. This is the first report on 14-acetylandrographolide’s
quantified antibacterial activity, and the crucial functional group of this ent-labdane that plays an important role in perturbing the morphogenesis of B. subtilis leading to cell death. |
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