血管紧张素转换酶基因多态性与原发性高血压病关系的研究──粤东地区人群研究

原发性高血压为一多因素性疾病，其遗传机制与多种基因变异有关，尤其与编码肾素血管紧张素系统的基因相关。为探测血管紧张素转换酶（ACE）基因多态性与原发性高血压发生的关系，本文应用聚合酶链反应检测粤东地区60例原发性高血压病患者和60例正常人ACE基因插入／缺失多态性。结果表明正常组缺失型等位基因出现的相对频率为0．375，原发性高血压组缺失型等位基因出现的相对频率为0．492，两者差别无显著意义（P＞0．05）。我们认为ACE基因插入／缺失多态性与原发性高血压无密切关系，不宜作为该地区原发性高血压的诊断基因。

Association of a Polymorphism of the Angiotensin I-Converting Enzyme with Essential Hypertention

To find the relationship between angiotensin I converting enzyme (ACE) gene and essential hypertention (EH), we use PCR to detect the insertion/deletion (I/D)polymorphism of the ACE gene of 60 healthy people and 60people who got the disease of essential hypertention, they all live in YueDong.The D allel gene frequnce is 0. 375 in control group and 0. 492 in EH group. The difference between them is not siginificante. It suggests that the I/D polymorphism of ACE gene is not associated with EH of the people in the district of YueDong.