| 贝尼地平对冠心病患者一氧化氮和内皮素的影响 |
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| 引用本文： | 卫丽,李学奇,张兰. 贝尼地平对冠心病患者一氧化氮和内皮素的影响[J]. 中国实用内科杂志, 2007, 27(9): 689-690 |
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| 作者姓名： | 卫丽 李学奇 张兰 |
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| 作者单位： | 哈尔滨医科大学附属第四医院心内科,黑龙江,哈尔滨,150001 |
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| 摘 要： | 目的探讨钙离子拮抗剂贝尼地平对冠心病患者一氧化氮(NO)和内皮素(ET-1)的影响。方法将2006年1～7月对哈尔滨医科大学第四医院心内科36例冠心病患者给予贝尼地平2～4mg/d,治疗8周,测定用药前及服药后第4、8周NO和ET-1水平。以40名相匹配健康体检者为对照组给予安慰剂口服。结果冠心病患者的NO较对照组明显降低[(7.46±3.36)μmol/L对(33.49±12.45)μmol/L,P<0.05],ET-1升高[(79.60±10.04)ng/L对(59.50±6.28)ng/L,P<0.05]。贝尼地平治疗前后比较NO升高[(28.24±14.92)μmol/L对(7.46±3.36)μmol/L,P<0.01],ET-1降低[(60.01±13.84)ng/L对(79.60±10.04)ng/L,P<0.01]。结论贝尼地平能升高冠心病患者的NO水平,降低ET-1水平,从而证明贝尼地平具有内皮保护作用。
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| 关 键 词： | 冠状动脉疾病 贝尼地平 一氧化氮 内皮素 |
| 文章编号： | 1005-2194(2007)09-0689-02 |
| 修稿时间： | 2006-10-15 |
Effect of benidipine on NO and ET-1 of patients with coronary heart diease |
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| WEI Li,LI Xue-qi,ZHANG Lan. Effect of benidipine on NO and ET-1 of patients with coronary heart diease[J]. Chinese Journal of Practical Internal Medicine, 2007, 27(9): 689-690 |
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| Authors: | WEI Li LI Xue-qi ZHANG Lan |
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| Abstract: | Objective To search for the effect of benidipine,a kind of Ca2 blocker,on NO and ET-1 of patients with coronary heart disease.Methods Benidipine(2~4 mg/d)were given to the patients with coronary heart disease diagnosed definitely for 8 weeks.Forty healthy candidates were enrolled in the control group,and their morning fasting blood were tested for NO and ET-1 levels at the 4th,8th week in order to compare with the control group.Results Blood NO level of CHD patients was lower and blood ET-1 level was higher than the control group remarkably.After treatment NO level was increased and ET-1 level was decreased separately.Conclusion Benidipine can increase NO level and decrease ET-1 level,which demonstrated the protective effect of benidipine for endothelia. |
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| Keywords: | Coronary disease Benidipine NO ET-1 |
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