甲氨蝶呤明胶微球经肝动脉灌注后近期毒性的实验研究

通过肝动脉灌注的实验研究旨在了解甲氨蝶呤明胶微球（ＭＴＸ－ｍｓ）的近期毒性作用，为这种新型化疗栓塞剂介入治疗肝癌的临床应用提供实验依据。经大白鼠肝动脉灌注后显示；与对照组和单纯ＭＴＸ化疗组比较，较大剂量的ＭＴｘ－ｍｓ可使动物血中ＡＬＴ和ＡＫＰ值暂时性升高，肝脏发生不同程度的变性坏死；１２天后肝组织坏死区小血管内仍可见大量微球滞留。其它主要脏器（心、脾、肺和肾脏）未发现与微球有关的病理改变。结果提示

Experimental Study of Methotrexate Microspheres'Shortterm Toxicity after Hepatic Arterial Infusion

The aim of the experimental study is to investigate shortterm toxicity of an initial domestic Methotrexate microspheres(MTX-ms)by hepatic arterial infusion in rats,provide some experimental bases for clinic interventional treatment of liver carcinoma with this new chemoembolization agent.Compareing with control group and MTX group, MTX-ms of largedoses could result in temporal rise of GPT and AKP,deterioration or necroses of animal's liver at different degrees,12 days later a number of microspheres could still be found in the small arteries of the necrotizing area.No pathological changes related to microsphere could be found in other main organs(heart,spleen,lung and kidney).Results suggested that chemoembolization effect of MTX-ms is relatively strong;for effectively oc- cluding blood flow of hepatic arteries on the level of small arteries.Meanwhile MTX-ms oc- clud blood supply of liver carcinoma,they may also cause damages of normal liver tissue. Clinically more attention ought to be paid to the dosage of MTX1 microspheres and thus avoid the overflow of more microspheres to the normal liver tissue causing damage.