多囊卵巢综合征患者用克罗米酚促排卵结局与相关因素的探讨

目的　探讨在多囊卵巢综合征 (PCOS)患者中影响克罗米酚 (CC)促排卵因素。方法　对 94例因多囊卵巢综合征不孕患者 ,用CC促排卵治疗。采用放射免疫方法测定卵泡刺激素 (FSH)、黄体生成素 (LH)、雌二醇 (E2 )、睾酮 (T)、雄烯二酮 (A)、泌乳素 (PRL)水平及胰岛素释放反应。分析了排卵结局与年龄、基础激素水平、胰岛素抵抗 (IR)、胰岛素反应曲线下面积 (AUCI)及体重指数 (BMI)之间的关系。结果　用克罗米酚促排卵 94个周期中排卵率为 5 5 2 % (5 2 / 94) ,未排卵组的基础血雄激素、LH、AUCI 和BMI均较排卵组高。结论　PCOS患者的高雄激素、高LH血症、IR、高BMI对促排卵的结局产生负影响。

The outcomes and related factors about inducing ovulation by clomiphene citrate in polycystic ovarian syndrome patients

Objective To study the factors which influence inducing ovulation by clomiphene citrate(cc) in polycystic ovarian syndrome(PCOS)patients.Methods\ 94 infertility PCOS patients were given CC to induce ovulation.The levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E 2),testosterone(T),androstenedione(A),prolactin(PRL)and insulin were tested by radioimmunoassay.Results\ CC therapy resulted in 55 2% ovulation in 94 cycles.The basal serum A,LH levels,AUC I and body mass index (BMI) in anovulation group were higher than those in ovulation groups.Conclusions\ The hyperandrogenesis,hyperlutemia,insulin resistance and high BMI had negative effects on induction of ovulation by CC in PCOS patients.