HbA1C、sRAGE、esRAGE、cRAGE与糖代谢异常患者冠状动脉钙化程度的相关性研究

目的通过检测不同糖代谢状态患者的糖化血红蛋白（HbAlC）、可溶性晚期糖基化终末产物受体（sRAGE）、内源性分泌型晚期糖基化终末产物受体（esRAGE）、裂解型晚期糖基化终末产物受体（cRAGE），探讨其与冠状动脉钙化严重程度的相关性。方法选取湖北医药学院附属太和医院2012年5—12月住院患者，设立糖尿病组（DM组，n=32）、糖耐量异常组（IGT组，n=28）、糖耐量正常组（Control组，n=24）。分别检测HbAlC、sRAGE、esRAGE、cRAGE水平，并评估其与冠状动脉钙化严重程度的相关性。结果三组患者HbAlC、sRAGE、esRAGE、cRAGE水平比较差异均有统计学意义，DM组〉IGT组〉Control组；冠状动脉钙化积分值也逐渐升高，与以上结果呈正相关（P〈0．05）。结论联合检测HbAIC、sRAGE、esRAGE、cRAGE可能成为预测不同糖代谢状态患者发生冠状动脉疾病等心血管事件的重要预测指标之一，也是评估病情严重程度及预后的重要因素之一。

Correlations between HbA1C,sRAGE, esRAGE,cRAGE and severity of coronary artery calcification

Objective To explore the correlation between severity of coronary artery calcification and the levels of glycosylated hemoglobin （HbA1C）, soluble receptor for advanced glycosylation end products （sRAGE）, endogenous secretory receptor for advanced glycosylation end products （esRAGE） and cleaved receptor for advanced glycosylation end products （eRAGE） in patients with different degree of glucose metabolism. Methods Hospitalized patients from May to December 2012 were divided into diabetes group （DM group, n=32）, impaired glucose tolerance group （IGT group, n= 28） and normal glucose tolerance group （Control group, n=24）. The levels of HbA1C, sRAGE, esRAGE and cRAGE were measured and correlated with the severity of coronary artery calcification. Results The level of HbA1C, sRAGE, esRAGE and cRAGE were statistically different in these three groups （DM group〉IGT group〉Control group）.The increase in the levels of HbA1C, sRAGE, esRAGE and cRAGE was correlated with the coronary artery calcium score （P〈0.05）. Conclusions Combined detection of HbA1C, sRAGE, esRAGE, cRAGE could be used to predict the state of glucose metabolism in patients with coronary artery disease and other cardiovascular events. It can also be used to evaluate the severity and in the prognosis of diabetes disease.