血清降钙素原变化与急性胰腺炎患者病情及转归的关系

目的探讨血清降钙素原(PCT)变化与急性胰腺炎患者病情及转归的关系。方法选取急性胰腺炎患者62例,根据统计分析的需要将其按照诊断分型、血清PCT浓度以及转归进行分组,并随机选取诊断为功能性胃肠病的门诊患者30例作为对照组,将各组间血清降钙素原浓度、APACHE II评分、并发症以及转归情况进行统计分析。结果重症急性胰腺炎(SAP)组、中症急性胰腺炎(MSAP)组、轻症急性胰腺炎(MAP)组、健康对照组血清PCT水平分别为(3.29±1.20)μg/L、(1.66±1.98)μg/L、(0.73±0.33)μg/L和(0.10±0.91)μg/L,顺次组间比较差异均有统计学意义(P0.01或P0.05),血清PCT水平与APACHE II评分呈正相关,病程中出现局部和(或)全身并发症者血清PCT水平显著高于无并发症者。结论 PCT对急性胰腺炎患者严重程度的评估及预后判断具有重要的临床意义。

The correlation of serum procalcitonin levels with the severity of acute pancreatitis

Objective To explore the value of serum level of procalcitonin in early assessment of the severity and prognosis of acute pancreatitis （AP）. Methods Sixty-two AP patients were selected as study objects, and thirty functional gastrointestinal disorder patients were set as control group. Serum procalcitonin concentrations were determined by Double Antibody Sandwich Enzyme-linked immunosorbant assay （DAS-ELISA）. The association of serum procalcitonin, the scores of APACHE II, complications and prognosis was analyzed. Results The serum procalcitonin levels of severe acute pancreatitis （SAP） group, mild severe acute pancreatitis（MSAP） group,mild acute pancreatitis（MAP） group and control group were （3.29±1.20） μg/L, （1.66±1.98）μg/L, （0.73±0.33）μg/L and （0.10±0.91 ） μg/L, respectively, and the differences amongs these groups were statistically significant （P〈0.01 or P〈0.05）.The procalcitonin level was positively correlated with the scores of APACHE II. The procalcitonin levels of patients with local and/or systemic complications were significantly higher than those without complications. Conclusion The serum levels of procalcitonin are significantly correlated with the severity of pancreatitis. The high level of serum procalcitonin is significantly correlated with complications.