广东某地区妇女高危型HPV感染特点及年龄结构分布

目的通过对门诊患者人乳头瘤病毒（HPV）基因型检测，分析本地区高危型HPV感染特点以及年龄构成分布。方法收集了8681例样本，采用导流杂交基因芯片技术进行21种HPV亚型基因型的分型检测。结果HPV总感染率为22．0％，高危型感染率为16．08％，以16亚型最多见（27．42％），其次是52亚型（21．82％）；高危型HPV感染以单一型为主（78．58％），多重型感以双重感染多见；不同年龄段的HPV感染率差异有统计学意义（xz=302．88，P〈0．01），不同年龄的高危型HPV感染率差异亦有统计学意义（x2=321．60，P〈0．01）。结论广东该地区高危型HPV感染率略高，且具有明显的年龄分布异质性，提示预防性疫苗的使用应考虑年龄因素。

Analysis of genital HPV infection in the high risk women in Guangdong

Objective To analyze the characteristics of high risk human papillomavirus （HPV） infection through the detection of HPV genotype. Method 8 681 samples were analyzed using flow-through hybridization and gene chip technique for the 21 HPV genotype. Results The HPV positive rate was 22.0%. The high-risk HPV infection rate was 16.08%. HPV16 （27.42%） was the most common HPV type, and it was followed by HPV52 （21.82%）. 78.58% of the HPV patients were infected by a single subtype of HPV. Double HPV infection was common among the patients with multiple HPV infection. There was a significant difference in the infection rate among the various age groups （P〈0.01）. Conclusions The infection rate in the high risk HPV patients in Gnangdong was high. The infection was age-specific, suggesting that characteristic should be taken into consideration in the application of HPV vaccines.