负荷量苯巴比妥联合持续静脉滴注地西泮治疗新生儿破伤风的临床研究

目的观察负荷量苯巴比妥及持续静脉滴注地西泮治疗新生儿破伤风（NT）的临床疗效。方法将2006—2010年在中山大学附属汕头医院治疗的63例破伤风新生儿按不同抗惊厥治疗方案进行分组，“圊顾性分析负荷量苯巴比妥20mg／kg肌注联合地西泮10mg／（kg·d）维持5灿g／（kg·min）静脉泵注治疗NT的临床疗效，并与传统抗惊厥治疗方法进行比较，对疗效结果进行统计学分析。结果负荷量苯巴比妥及持续静脉滴注地西泮治疗NT与传统方式比较，其痉挛控制时间快，住院时间短，肺炎、痉挛窒息、呼吸衰竭等并发症发生率及死亡率低，治愈率高，差异均有统计学意义（P〈0．05）。结论负荷量苯巴比妥及持续静脉滴注地西泮治疗NT效果好，优于传统方式，值得临床推广。

The clinical study of loading dose of phenobarbital and continuous intravenous infusion of diazepam on neonatal tetanus

Objective To observe the clinical efficacy of loading dose of phenobarbital and continuous intravenous infusion of diazepam on neonatal tetanus （NT）. Methods From 2006 to 2010, 63 cases of neonatal tetanus were divided into different sub-groups according to anticonvulsant programs. A retrospective study of clinical efficacy of loading dose of Phenobarbital （20 mg/kg） IM injection and Diazepam （10 mg.kg-~ dq）was infused at a rate of 10 mg/（kg.d） using by continuous infusion pump on neonatal tetanus, then compare with conventional anticonvulsant. Results The sub-group of loading dose of phenobarbital and continuous intravenous infusion of diazepam had shorter spasm control time, shorter hospital stay, lower incidence of pneumonia, convulsions, asphyxia, respiratory failure mortality rates and other complications, and had higher cure rate （P〈0.05）. Conclusion The treatment of loading dose of phenobarbital and continuous intravenous infusion of diazepam on neonatal tetanus （NT） is superior to traditional treatment.