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Three advanced gastric cancer patients successfully treated by combination therapy of paclitaxel and cisplatin
Authors:Yamada Takeshi  Tanaka Noritake  Yokoi Kimiyoshi  Ishikawa Noriyuki  Seya Tomoko  Horiba Kouji  Kanazawa Yoshikazu  Shirakawa Takashi  Ohkawa Keiichi  Kudoh Hidenori  Koizumi Michihiro  Yoshioka Masato  Shinji Seiichi  Katsuta Miwako  Yamashita Kiyohiko  Tajiri Takashi
Institution:Dept. of Surgery, Nippon Medical School, Chiba Hokusou Hospital.
Abstract:We report 3 gastric cancer patients with peritoneal dissemination who were successfully treated with weekly paclitaxel and cisplatin. The patients were 2 men and 1 woman from 57 to 70 years in age. The histological types were 2 poorly-differentiated adenocarcinomas and 1 moderately-differentiated adenocarcinoma. Intravenous infusion of PTX (80 mg/m(2)) and CDDP (25 mg/m(2)) after short premedication was continued for 3 weeks followed by 1 week rest. Ascites improved only after administration of 1 course in all patients.PTX/CDDP is thought to be an effective chemotherapy showing acceptable toxicity against advanced gastric cancer with ascites.
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