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滇桑茎皮中抗氧化活性成分研究
引用本文:崔锡强,王洪庆,刘超,陈若芸.滇桑茎皮中抗氧化活性成分研究[J].中国中药杂志,2008,33(13):1569-1572.
作者姓名:崔锡强  王洪庆  刘超  陈若芸
作者单位:中国医学科学院,中国协和医科大学,药物研究所,中草药物质基础与资源利用教育部重点实验室,北京,100050
摘    要:目的:研究滇桑茎皮中的抗氧化活性成分。方法:应用色谱技术分离纯化,通过理化性质和波谱学方法鉴定化合物的结构。结果:从95%乙醇提取物中分离得到8个酚类化合物,分别鉴定为:mulberrofuran E(1),mulberrofuran K(2),albanol B(3),kuwanon H(4),resveratrol(5),moracin M(6),morachalcone A(7),3′,5′,2,4-tetrahydroxy-4-(3-methyl-1-butenyl)stilbene(8)。结论:化合物1~8都为首次从该种植物中分离得到。抗氧化筛选结果表明,化合物2,3,6,8显示出较好的抗氧化活性。

关 键 词:滇桑  抗氧化活性  酚类
收稿时间:2007/10/28 0:00:00

Study of anti-oxidant phenolic compounds from stem barks of Morus yunanensis
CUI Xi-qiang; WANG Hong-qing; LIU Chao; CHEN Ruo-yun.Study of anti-oxidant phenolic compounds from stem barks of Morus yunanensis[J].China Journal of Chinese Materia Medica,2008,33(13):1569-1572.
Authors:CUI Xi-qiang; WANG Hong-qing; LIU Chao; CHEN Ruo-yun
Institution:Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Abstract:OBJECTIVE: To study anti-oxidant phenolic compounds from stem barks of Morus yunanensis. METHOD: Isolation and purification were carried out by silica gel, Sephadex LH -20 and RP - 18 column chromatography. The chemical structures of constituents were elucidated on the basis of physicochemical properties and spectral data. RESULT: Eight phenolic compounds were isolated and identified as: mulberrofuran E (1), mulberrofuran K (2), albanol B (3), kuwanon H (4), resveratrol (5), moracin M (6), morachalcone A (7), 3', 5', 2, 4-tetrahydroxy-4-(3-methyl-1-butenyl) stilbene (8). CONCLUSION: All the compounds were isolated from the plant for the first time, and compounds 2, 3, 6, 8 showed potent anti-oxidation activities.
Keywords:Morus yunanensis  anti-oxidation activity  phenolic
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