Neurohypophyseal Hormone-Responsive Adenylate Cyclase from Mammalian Kidney |
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Authors: | Thomas Dou?a Oscar Hechter Irving L. Schwartz Roderich Walter |
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Affiliation: | *Department of Physiology, Northwestern Medical School, 303 East Chicago Avenue, Chicago, Illinois 60611;Department of Physiology, Mount Sinai School of Medicine of the City University of New York, 10 East 102nd Street, New York, N.Y. 10029 |
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Abstract: | The investigation was undertaken to evaluate the direct stimulatory effects of neurohypophyseal hormones upon adenylate cyclase activity in a cell-free, particulate fraction derived from the kidney medulla of various mammalian species. The relative affinity of neurohypophyseal hormones for the receptor component of the adenylate cyclase system (as defined by the concentration of hormone required for half-maximal stimulation) had the order [8-arginine]-vasopressin > [8-lysine]-vasopressin oxytocin (AVP > LVP OT) for rat, mouse, rabbit, and ox; in the pig, the order was LVP > AVP OT. The relative affinities of the three hormones in rat and pig cyclase systems were found to correspond with the relative antidiuretic potencies of these hormones in the intact rat and pig. These findings show that the renal receptor for neurohypophyseal hormones in a particular species exhibits the highest affinity for the specific antidiuretic hormone that occurs naturally in that species. |
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