髓过氧化物酶基因多态性与胃癌易感性的关系

流行病学研究表明髓过氧化物酶（MPO）-463G→A多态性与多种疾病相关.目的：探讨MPO基因多态性与胃癌易感性之间的关系.方法：应用PCR-RFLP检测117例胃癌患者和105例对照者的MPO-463G→A多态性,比较两组MPO基因型频率和等位基因频率,分析MPO基因多态性与胃癌危险性的关系,并行分层分析探讨性别、年龄、吸烟状况、幽门螺杆菌（H.pylori）感染和胃癌家族史对胃癌的影响.结果：胃癌组GA和 AA基因型频率显著低于对照组（GA：25.6%对37.1%,AA：3.4%对11.4%,P〈0.05）,A等位基因频率亦明显降低（16.2%对30.0%,P〈0.05）.与GG基因型患者相比,携带MPO-463GA/AA基因型者罹患胃癌的危险性明显降低（OR=0.43,95% CI：0.25-0.75）.分层分析示男性、年龄≤60岁、不吸烟、H.pylori感染阴性和无胃癌家族史人群携带GA/AA基因型较携带GG基因型者罹患胃癌的危险性降低.结论：MPO基因多态性与胃癌易感性相关,A等位基因对胃癌易感性具有保护作用.

Correlation of Myeloperoxidase Gene Polymorphism with Susceptibility to Gastric Cancer

Several epidemiological studies have shown that myeloperoxidase(MPO)-463G→A polymorphism is related with many kinds of diseases.Aims:To investigate the correlation of MPO gene polymorphism with susceptibility to gastric cancer.Methods:A total of 117 gastric cancer patients and 105 controls were enrolled.PCR-RFLP was used to determine MPO-463G→A polymorphism.Frequencies of genotype and allele were compared between the two groups.The association between MPO gene polymorphism and risk of gastric cancer was analyzed.Stratification analysis by gender, age,smoking status,Helicobacter pylori(H.pylori) infection and family history of gastric cancer was performed.Results: The frequencies of GA and AA genotype in gastric cancer group were significantly decreased than those in control group (GA:25.6%vs.37.1%,AA:3.4%vs.11.4%,P<0.05),and frequency of A allele was significantly decreased(16.2%vs. 30.0%,P<0.05).Compared with MPO-463GG genotype,patients with GA/AA genotype had a significantly decreased risk of gastric cancer(OR=0.43,95%CI:0.25-0.75).Stratification analysis showed that in GA/AA genotype patients with male, age equal to or less than 60 years,no smoking,H.pylori-negative or without family history of gastric cancer,the risk of gastric cancer was lower than that in patients with GG genotype.Conclusions:MPO gene polymorphism is associated with susceptibility to gastric cancer.A allele may decrease the risk of gastric cancer.