Allergy as an epithelial barrier disease |
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| Authors: | Mattila Pirkko Joenväärä Sakari Renkonen Jutta Toppila-Salmi Sanna Renkonen Risto |
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| Affiliation: | Transplantation Laboratory & Infection Biology Research Program, Haartman Institute, University of Helsinki & Helsinki University Central Hospital, HUSLAB, Helsinki, Finland. risto.renkonen@helsinki.fi. |
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| Abstract: | ABSTRACT: The objective of this review is to focus on putative modified epithelial functions related to allergy. The dysregulation of the epithelial barrier might result in the allergen uptake, which could be the primary defect in the pathogenesis of allergic reaction. We review the literature of the role of respiratory epithelium as an active barrier, how allergens are transported through it and how it senses the hostile environmental allergens and other dangerous stimuli. |
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