| 474例抗肿瘤药品不良反应/事件报告分析 |
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| 引用本文： | 陈海云. 474例抗肿瘤药品不良反应/事件报告分析[J]. 中国药物警戒, 2013, 0(11): 676-678,682 |
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| 作者姓名： | 陈海云 |
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| 作者单位： | 淮安市药品不良反应监测中心,江苏淮安223001 |
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| 摘 要： | 目的对淮安市抗肿瘤药品不良反应事件发生情况及特点进行分析,为临床合理用药提供参考。方法采用回顾性分类统计,对淮安市2004年1月至2012年12月共474例的抗肿瘤药品不良反应/事件病例报告进行综合分析。结果抗肿瘤药品不良反应涉及中老年患者最多;顺铂、紫杉醇、奥沙利铂所致药品不良反应居前3位;静脉用药不良反应发生率最高;抗肿瘤药品不良反应累及的系统-器官以血液系统损害最常见。结论临床上应加强对抗肿瘤药品不良反应的预防和监测。
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| 关 键 词： | 抗肿瘤药物 药品不良反应/事件 合理用药 |
Analysis of 474 Adverse Drug Reaction/Event Cases Induced by Anticancer Drugs |
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| CHEN Hai-yun. Analysis of 474 Adverse Drug Reaction/Event Cases Induced by Anticancer Drugs[J]. Chinese JOurnal of Pharmacovigilance, 2013, 0(11): 676-678,682 |
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| Authors: | CHEN Hai-yun |
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| Affiliation: | CHEN Hai-yun (Huaian Center for ADR Monitoring, Jiangsu HuMan 223001, China) |
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| Abstract: | Objective To investigate and analyze the characteristics of the adverse drug reaction/event induced by anticancer drugs in Huaian so as to provide reference for the rational use of drugs. Methods 474 AD1K/ADE cases induced by anticancer drugs in Huaian from January 2004 to December 2012 were analyzed retrospectively. Results The case reports showed that the middle aged and elderly people were the main part in the patients. Incidence rate of AD1K/ADE induced by cisplatin, paclitaxel and oxaliplatin occupied the top three in the sequence, and drugs for in- travenous administration resulted in the highest rate. Most AD1K/ADE cases involved the blood system. Conclusion More attentions should be paid to AD1K/ADE induced by anticancer drugs to ensure safe and rational drug use. |
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| Keywords: | anticancer drugs adverse drug reaction/event（ADR/ADE） rational use of drugs |
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