| 毒理基因组学在免疫毒理学研究中的应用 |
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| 引用本文： | 林志,黄瑛,张頔,杨艳伟,吕建军,屈哲,霍桂桃,孙建宁,李波.毒理基因组学在免疫毒理学研究中的应用[J].药物评价研究,2013(5):321-326. |
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| 作者姓名： | 林志 黄瑛 张頔 杨艳伟 吕建军 屈哲 霍桂桃 孙建宁 李波 |
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| 作者单位： | [1]中国食品药品检定研究院,北京100176 [2]北京中医药大学,北京100029 |
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| 基金项目： | 国家“重大新药创新”科技重大专项-药物安全评价技术平台（2012ZX09302001） |
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| 摘 要： | 毒理基因组学是利用DNA微阵列技术,研究化合物作用于机体后的基因变化,将组学技术与传统毒理学及组织病理学相结合,评价和预测化合物的毒性的一门学科。随着毒理基因组学的广泛应用,免疫毒理学领域也开始利用基因表达谱来分析化合物的免疫毒性。目前认为免疫毒理基因组学可能在下述3个方面具有较高的应用价值,即免疫毒性物质的筛选、免疫毒性作用机制的研究以及免疫毒性风险评估。现围绕这3个方面,对毒理基因组学在免疫毒理学领域中的应用进行阐述。
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| 关 键 词： | 毒理基因组 免疫毒理学 药物安全 风险评估 |
Application of toxicogenomics in immune toxicology |
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| LIN Zhi;HUANG Ying;ZHANG Di;YANG Yan-wei;LV Jiang-jun;QU Zhe;HUO Gui-tao;SUN Jian-ning;LI Bo.Application of toxicogenomics in immune toxicology[J].Drug Evaluation Research,2013(5):321-326. |
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| Authors: | LIN Zhi;HUANG Ying;ZHANG Di;YANG Yan-wei;LV Jiang-jun;QU Zhe;HUO Gui-tao;SUN Jian-ning;LI Bo |
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| Institution: | LIN Zhi;HUANG Ying;ZHANG Di;YANG Yan-wei;LV Jiang-jun;QU Zhe;HUO Gui-tao;SUN Jian-ning;LI Bo;National Institutes for Food and Drug Control;Beijing University of Chinese Medicine; |
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| Abstract: | Toxicogenomics is the subject that researches on the genetic changes by using DNA microarray technology after the compounds acting on the body.It combines omics technologies with conventional toxicology and histopathology in order to evaluate and predict the toxicity of a compound.With the wide application of toxicogenomics,it begins to analyze the immunotoxicity of compounds by using gene expression profiling in immunotoxicity.Currently,scientists believe that the immunotoxicogenomics may have higher value in the following three areas,immunotoxicity screening substances,immune mechanisms of toxicity,and immunotoxicity risk assessment.Therefore,it was discussed in these three aspects of application of immune toxicology in this paper. |
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| Keywords: | toxicogenomics immunotoxicity drug safety risk assessment |
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