调经补血丸主要药效学研究

目的研究调经补血丸的补血养血、理气通经及镇痛作用。方法采用大鼠气滞血瘀模型、失血性血虚小鼠模型、缩宫素疼痛模型及缩宫素引起的大鼠子宫条收缩模型,考察调经补血丸的药理作用。结果调经补血丸在0.3~2.4 g/kg剂量下,ig给药能够非常显著地降低气滞血瘀模型大鼠的全血黏度和血浆黏度;能够显著增加失血性血虚小鼠红细胞数量和血红蛋白量;能够显著地减少缩宫素所致小鼠扭体次数;在终质量浓度3.6×10-5、1.2×10 4、3.6×10 4、1.2×10 3g/mL对缩宫素引起的大鼠子宫条收缩有非常显著的拮抗作用。结论调经补血丸具有较好的活血化瘀、补血养血、理气通经及镇痛作用。

Studies on main pharmacodynamics of Tiaojingbuxue Pill

Objective To investigate the function of Tiaojingbuxue Pill in nourishing blood,promoting menstruation by regulating Qi and analgesia.Methods The pharmacological action of Tiaojingbuxue Pill was observed by rats model of Qi-stagnation and blood stasis,hemorrhagic deficiency models of mice,oxytocin pain models,and uterine contraction models of rats induced by oxytocin.Results Tiaojingbuxue Pill（ig 0.3—2.4 g/kg） could significantly reduce the blood viscosity and plasma viscosity of rats with Qistagnation and blood stasis,also could markedly increase the amounts of erythrocyte and hemoglobin of mice with hemorrhagic anemia and lower the frequency of body-torsion of mice induced by oxytocin.Meanwhile,Tiaojingbuxue Pill（3.6 × 10 5,1.2 × 10 4,3.6 × 10 4,and 1.2×10 3g/mL） had antagonistic action on uterine contraction of rats induced by oxytocin.Conclusion Tiaojingbuxue Pill has the significant effect of activating blood circulation to dissipate blood stasis,nourishing blood,promoting menstruation by regulating Qi and analgesia.