Imaging features of thalassemia |
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Authors: | M Tunacı A Tunacı G Engin B Özkorkmaz G Dinçol G Acunaş B Acunaş |
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Institution: | (1) Department of Radiology, Faculty of Medicine, Istanbul University, Istanbul, Turkey, TR;(2) Department of Internal Medicine, Section of Hematology, Faculty of Medicine, Istanbul University, Istanbul, Turkey, TR |
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Abstract: | Thalassemia is a kind of chronic, inherited, microcytic anemia characterized by defective hemoglobin synthesis and ineffective
erythropoiesis. In all thalassemias clinical features that result from anemia, transfusional, and absorptive iron overload
are similar but vary in severity. The radiographic features of β-thalassemia are due in large part to marrow hyperplasia. Markedly expanded marrow space lead to various skeletal manifestations
including spine, skull, facial bones, and ribs. Extramedullary hematopoiesis (ExmH), hemosiderosis, and cholelithiasis are
among the non-skeletal manifestations of thalassemia. The skeletal X-ray findings show characteristics of chronic overactivity
of the marrow. In this article both skeletal and non-skeletal manifestations of thalassemia are discussed with an overview
of X-ray findings, including MRI and CT findings.
Received: 21 August 1999; Revision received: 22 December 1999; Accepted: 15 February 1999 |
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Keywords: | : Thalassemia Extramedullary hematopoiesis MRI CT |
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