| 双氯芬酸钠合成工艺研究 |
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| 引用本文： | 陈芬儿 万江陵. 双氯芬酸钠合成工艺研究[J]. 中国医药工业杂志, 1995, 26(4): 145-148 |
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| 作者姓名： | 陈芬儿 万江陵 |
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| 作者单位： | 武汉化工学院合成药物研究室，湖南制药厂，杭州胡庆余堂中药厂 |
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| 摘 要： | 以环己酮为起始原料，经氯化、缩合、热解脱氯化氢制成Ｎ－苯基－２，６－二氯苯胺（４），继而经酰胺化、环合、水解开环得目的物，总收率６１％。其中氯化反应以亚磷酸三苯酯代替价昂的三苯基膦。缩合反应以冰乙酸代替无水四氯化钛。对酰胺化、环合、水解开环等反应条件均有所改进。
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| 关 键 词： | 双氯芬酸钠 二氯苯胺 合成 |
SYNTHESIS OF DICLOFENAC SODIUM FROM CYCLOHEXANONE |
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| CHEN Fen-Er,WAN Jiang-Ling,GUAN Chun-Sheng,DENG Yan,ZHANG Hai-Yun. SYNTHESIS OF DICLOFENAC SODIUM FROM CYCLOHEXANONE[J]. , 1995, 26(4): 145-148 |
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| Authors: | CHEN Fen-Er WAN Jiang-Ling GUAN Chun-Sheng DENG Yan ZHANG Hai-Yun |
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| Abstract: | Diclofenac sodium was synthesised from cyclohexanone in about 61% overall yield via six-step reaction sequence.Triphenyl phosphite was used in the chlorination step with a catalytic amount of Bz_2O_2 at the later stage and glacial acetic acid in the anil formation step. |
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| Keywords: | diclofenac sodium N-peny1-2 6-dichloraniline synthesis |
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