Tumour necrosis factor alfa and glucose levels in sera of mice infected with coxsackie B4 and A7 viruses. |
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Authors: | S A Bopegamage A Petrovicová |
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Affiliation: | Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic. |
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Abstract: | Cytokines have been suggested to play an important role in the pathogenesis of type I diabetes mellitus through their direct and indirect effects on the pancreatic islet cells. We studied the time course of tumour necrosis factor alpha (TNF-alpha) and glucose levels in the sera of mice infected with coxsackie B4 and A7 viruses. Two correlating peaks of TNF-alpha and glucose were found. These results suggest the involvement of TNF-alpha in the damage of the insulin producing cells and thus an immunity-related inflammatory process. |
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