多西他赛与甘氨双唑钠在鼻咽癌放射治疗中增敏疗效比较

目的:比较多西他赛与甘氨双唑钠的放射增敏疗效。方法:105例中晚期鼻咽癌患者随机分为多西他赛组、甘氨双唑钠组、对照组。在放疗全程中,多西他赛组每周1次静脉滴注多西他赛40mg,甘氨双唑钠组每周一、三、五静脉滴注甘氨双唑钠1000mg,共用药7周。对照组仅单纯放疗。结果:多西他赛组和甘氨双唑钠组在提高疗效、肿瘤消退时放射剂量方面与对照组比较有显著性差异(P<0·05),多西他赛组与甘氨双唑钠组比较也有显著性差异(P<0·05),但毒副反应无显著性差异(P>0·05)。结论:低剂量多西他赛在放射增敏方面疗效优于甘氨双唑钠,对远处转移的控制更为有效,毒副反应不明显。

Radiosensitization Effect of Docetaxei versus Sodium Glycididazole for Nasopharyngeal Carcinoma

OBJECTIVE： To evaluate the radiosensitization effect of docetaxel versus sodium glyci - didazole. METHODS： A total of 105 patients with intermediate or advanced stage nasopharyngeal carcinoma were randomly assigned to receive docetaxel 40 mg once a week plus radiotherapy or sodium glycididazole 1 000 mg three times a week （Monday, Wednesday and Friday） plus radiotherapy for a total of 7 weeks, or radiotherapy only （control group） . RESULTS： There were significant differences between docetaxel group or sodium glycididazole group and control group in sensitization efficiency and radiation dose on tumor regression（P 〈 0.05）, and which were also significantly different between the docetaxel group and the sodium glycididazole group（P 〈 0.05）. But the side effects between the two groups showed no significant difference（P 〉0.05）. CONCLUSION： Lower dose docetaxel is better than sodium glycididazole in radiosensitization efficiency for advanced nasopharyngeal carcinoma, especially in controlling the metastasis, yet it has minimal side effect.