Facteurs de la variation de la fréquence cardiaque maximale: hypothèse «enképhalinique |
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Authors: | Y Semmoum A Younes J Coudert |
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Institution: | 1Laboratoire de physiologie-biologie du sport, faculté de médecine, place Henri-Dunant, BP 38, 63001 ClermontFerrand, France;2département de biologie appliquée, IUT, université d'Auvergne, 63001 Clermont-Ferrand, France |
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Abstract: | To try to explain the decrease in maximal heart rate under different situations (ie, chronic hypoxia, ageing, proteino-energetic malnutrition), cardiac concentration and flow of leucine-encephalin peptide in isolated and perfused hearts were studied in rats. The heart leucine-encephalin concentration which was 301 ± 60 fmol/g before perfusion, increased up to 543 ± 125 fmol/g after perfusion (1 h). The total release during perfusion was four times the initial concentration. Concerning the antagonism of leucine-encephalin on cardiotropic adrenergic effects on isolated cardiomyocytes, it is possible to propose this mechanism to explain totally or partially the decrease in maximal heart rate under particular situations. |
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Keywords: | Author Keywords: enké phaline c&oelig ur isolé stress caté cholamines |
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