Phyllodes tumours of the breast: Outcomes and recurrence after excision |
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| Affiliation: | 1. Providence Breast Centre, Mount Saint Joseph Hospital, 3080 Prince Edward Street, Vancouver, BC, V5T 3N4, Canada;2. Department of Surgery, Faculty of Medicine, University of British Columbia, 2775 Laurel Street, Vancouver, BC, V5Z 1M9, Canada;1. BC Cancer-Sindi Ahluwalia Hawkins Centre, Dept. of Surgical Oncology, 399 Royal Ave, Kelowna, BC, V1Y 5L3, Canada;2. University of British Columbia Southern Medical Program, 2312 Pandosy Street, Kelowna, BC, V1Y 1T3, Canada;1. Division of General Surgery, Department of Surgery, Schulich Medicine and Dentistry, Western University, London, ON, N6A 5A5, Canada;2. MD Undergraduate Program, Faculty of Medicine, University of British Columbia, 2194 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada;3. School of Population and Public Health, University of British Columbia, 2206 East Mall, Vancouver, BC, V6T 1Z3, Canada;4. Providence Breast Centre, Mount Saint Joseph Hospital, 3080 Prince Edward Street, Vancouver, BC, V5T 3N4, Canada;5. Department of Surgery, Faculty of Medicine, University of British Columbia, 2775 Laurel Street, Vancouver, BC, V5Z 1M9, Canada;1. Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada;2. Department of Surgery, University of British Columbia, Island Medical Program, Victoria, British Columbia, Canada;1. Department of Surgery, Madigan Army Medical Center, Tacoma, WA, USA;2. Department of Surgery, MultiCare Allenmore Hospital, Tacoma, WA, USA;1. Oregon Health and Science University, Mail Code L223, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA;2. Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA;3. Oregon Health and Science University, Mail Code L611, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA |
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| Abstract: | IntroductionWide excision margins are traditionally recommended for phyllodes tumours of the breast to reduce recurrence. Recent studies suggest margin status and histopathological features, excluding margin width, influence recurrence. This study evaluated treatment outcomes for phyllodes tumours and examined predictors of recurrence.MethodsClinical and follow-up information for phyllodes tumours patients treated between 2008 and 2017 were obtained from chart review. Tumour subtype and histopathological features were determined from pathology reports. Primary endpoints were recurrence rate and time to recurrence or mortality.ResultsAmong 96 patients, there were 6 local and 1 distant recurrences. Overall recurrence rate was 7.3% and average time-to-recurrence was 13.7 months. Tumour size, margin status, necrosis, and mitoses were associated with recurrence; margin width was not. Two deaths (2.1%) from malignant phyllodes occurred.ConclusionsMultiple histopathological features influence phyllodes recurrence. Wide excision and re-excising positive margins for benign tumours was not beneficial. |
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| Keywords: | Phyllodes Breast tumor Fibroepithelial Recurrence Excision |
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