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Human Granulocytic Anaplasmosis,Japan |
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| Authors: | Norio Ohashi Gaowa Wuritu Fumihiko Kawamori Dongxing Wu Yuko Yoshikawa Seizou Chiya Kazutoshi Fukunaga Toyohiko Funato Masaaki Shiojiri Hideki Nakajima Yoshiji Hamauzu Ai Takano Hiroki Kawabata Shuji Ando Toshio Kishimoto |
| Abstract: | We retrospectively confirmed 2 cases of human Anaplasma phagocytophilum infection. Patient blood samples contained unique p44/msp2 for the pathogen, and antibodies bound to A. phagocytophilum antigens propagated in THP-1 rather than HL60 cells. Unless both cell lines are used for serodiagnosis of rickettsiosis-like infections, cases of human granulocytic anaplasmosis could go undetected. |
| Keywords: | Anaplasma phagocytophilum anaplasmosis human granulocytic anaplasmosis Rickettsia japonica Orientia tsutsugamushi rickettsiosis p44/msp2 16S rDNA coinfection Japan spotted fever group rickettsia ticks bacteria |