Relationship of patient age to tumor factors and outcomes among patients undergoing sentinel node biopsy for melanoma |
| |
| Affiliation: | 1. School of Medicine, Oregon Health & Science University, Portland, OR, USA;2. Department of Surgery, Division of Surgical Oncology, Oregon Health & Science University, Portland, OR, USA;3. School of Public Health, Texas A and M University, College Station, TX, USA;1. Department of Surgery, Madigan Army Medical Center, Tacoma, WA, USA;2. Department of Surgery, Scripps Mercy Hospital, San Diego, CA, USA;1. Oregon Health & Science University, Portland, OR, USA;2. University of California San Francisco, San Francisco, CA, USA;1. Trauma Service, Scripps Mercy Hospital, 4077 Fifth Avenue, San Diego, CA, 92103, USA;2. Pharmacy Department, Scripps Mercy Hospital, 4077 Fifth Avenue, San Diego, CA, 92103, USA;1. University of Washington School of Medicine, Seattle, WA, 98195, USA;2. Institute for Disease Modeling, Bellevue, WA, 98005, USA;3. Seattle Children’s Hospital, Seattle, WA, 98105, USA;4. Seattle Children’s Research Institute, Seattle, WA, 98101, USA;1. Department of Surgery, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA;2. School of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA;3. Somali Health Board, 625 Strander Blvd Building B, Tukwila, Washington, 98188, USA;4. School of Social Work, University of Washington, Seattle, WA, USA;5. Harborview Injury Prevention and Research Center, University of Washington, Seattle, WA, USA;6. Department of Anesthesiology, University of Washington, 1959 NE Pacific St, Seattle, WA, 98195, USA;7. Seattle and King County Public Health, 401 5th Ave, Seattle, WA, 98104, USA;8. Department of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA;9. Department of Global Health, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA;10. Department of Pediatrics, University of Washington, 1959 NE Pacific St, Seattle, WA, 98195, USA |
| |
| Abstract: | IntroductionPatient age has been intermittently associated with demographics and outcomes in cutaneous melanoma. We looked at the association of age and patient demographics, tumor features, and melanoma-related outcomes in patients undergoing sentinel lymph node (SLN) biopsy for melanoma.MethodsWe reviewed demographics (age, gender), tumor features (mean Breslow thickness, ulceration, SLN positivity rates), and outcomes (all-site relapse, progression to stage IV, death from melanoma, complications) from a university-based prospective database of 1633 patients. Patients were grouped by decade of age and the impact of age was examined by univariable and multivariable analyses.ResultsIncreasing age was directly associated with number of patients referred for SLN biopsy, male gender, head and neck (H&N) tumor location, mean Breslow thickness, tumor ulceration, and with all –site relapse, progression to stage IV, death from melanoma and complication rates. Increasing age was indirectly associated with SLN positivity rates. Comparing ages <30 with ages >60, these trends reached statistical significance for male gender, H&N location, SLN positivity, all-site relapse, progression to stage IV (development of metastases) and death from melanoma.ConclusionsReferrals for SLN biopsy increase with increasing patient age, yet increasing age is associated with lower SLN positivity rates. This occurs despite the fact that older patients have thicker, more ulcerated tumors, and higher melanoma-related relapse and death rates. |
| |
| Keywords: | Melanoma Age Sentinel node biopsy |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
