Breast cancer risk assessment in patients who test negative for a hereditary cancer syndrome |
| |
| Institution: | 1. Department of Surgery, University of Kansas School of Medicine–Wichita, Wichita, KS, USA;2. Department of Preventive Medicine and Public Health, University of Kansas School of Medicine–Wichita, Wichita, KS, USA;3. Ascension Via Christi Cancer Center Outreach and Risk Assessment, Wichita, KS, USA;4. Office of Research, University of Kansas School of Medicine–Wichita, Wichita, KS, USA;5. Department of Surgery, Ascension Via Christi Clinic, Wichita, KS, USA;1. The Ohio State University Wexner Medical Center and James Cancer Hospital, Columbus, OH, USA;2. Mayo Clinic, Rochester, MN, USA;3. MD Anderson Cancer Center, Houston, TX, USA;4. Moffitt Cancer Center, Tampa, FL, USA;5. University of California San Diego, San Diego, CA, USA;6. Medical College of Wisconsin, Milkwaukee, WI, USA;7. Emory University, Atlanta, GA, USA;8. University of Cincinnati, Cincinnati, OH, USA;9. University of Massachusetts Memorial Medical Center, Worcester, MA, USA;10. Johns Hopkins University, Baltimore, MD, USA;11. City of Hope, Duarte, CA, USA;12. University of Wisconsin, Madison, WI, USA;1. Advocate Aurora Health, United States;2. University of Pittsburgh Department of Surgery, United States;3. Tulane University School of Medicine, United States;1. Loyola University Chicago Stritch School of Medicine, USA;2. University of Pittsburgh School of Medicine, USA;3. Department of Surgery, Loyola University Medical Center, USA;4. Department of Surgery, University of South Florida, USA |
| |
| Abstract: | BackgroundThe majority of women who undergo genetic testing due to a significant family history of breast cancer will receive a negative result. The purpose of this study was to calculate the lifetime risk of breast cancer in women undergoing genetic counseling who received an uninformative genetic test result.MethodsA retrospective chart review of mutation-negative women presenting to a cancer risk assessment clinic was performed. Lifetime risks of breast cancer were calculated using the Claus, Gail, and Tyrer-Cuzick risk assessment models.ResultsApproximately half (51%) of the women were classified as high-risk by at least one risk assessment model. The Tyrer-Cuzick model identified the highest proportion (43.2%) of patients as high-risk. Four percent (n = 4) of the sample was considered high-risk by all three models.ConclusionsMore than half (51%) of women who underwent genetic counseling and received an uninformative negative genetic test result had a significantly elevated risk for the development of breast cancer. It is, therefore, imperative that women do not conclude that a negative genetic test result represents a lack of risk. |
| |
| Keywords: | Breast cancer risk assessment Genetic counseling High-risk Uninformative result Negative result |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
