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CXC-chemokines KC and macrophage inflammatory protein-2 (MIP-2) synergistically induce leukocyte recruitment to the central nervous system in rats |
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| Authors: | Zwijnenburg Petra J G Polfliet Machteld M J Florquin Sandrine van den Berg Timo K Dijkstra Christine D van Deventer Sander J H Roord John J van der Poll Tom van Furth A Marceline |
| Affiliation: | Department of Pediatrics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. p.j.zwijnenburg@amc.uva.nl |
| Abstract: | Intracisternal injection of the CXC-chemokines KC or macrophage inflammatory protein (MIP)-2 induced a pleocytosis in the cerebrospinal fluid (CSF) of rats in a dose dependent way. MIP-2 was much more potent than KC. The concurrent injection of both chemokines revealed a profound synergistic effect on leukocyte recruitment into CSF. |
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