| 针刺镇痛中突触后抑制和阿片肽、GABA与P物质的关系 |
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| 引用本文： | 方宗仁 于琴. 针刺镇痛中突触后抑制和阿片肽、GABA与P物质的关系[J]. 针刺研究, 1993, 18(1): 64-67 |
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| 作者姓名： | 方宗仁 于琴 |
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| 作者单位： | 中国中医研究院针灸研究所，中国中医研究院针灸研究所，中国中医研究院针灸研究所 北京 100700，北京 100700，北京 100700 |
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| 摘 要： | 在麻醉大鼠脊髓背角神经记录投射神经元电活动,以神经元的逆向动作电位潜伏期为突触后抑制指标。电针足三里和三阴交穴使潜伏期延长0.111±0.022ms(N=12,P<0.001)。荷包牡丹碱组(N=12)电针仅延长0.010±0.04ms,与电针组有统计学差异。纳洛(?)组(N=12)和 SP 抗血清组(N=12)电针使潜伏期发生有意义的变化。实验表明 r-氨基丁酸,阿片肽和 P 物质可能参与电针的突触后抑制效应。
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| 关 键 词： | 针刺镇痛 脊髓背角神经元 突触后抑制 r-氨基丁酸 阿片肽 P 物质 |
THE CORRELATION BETWEEN POSTSYNAPTIC INHIBITION AND GABA、OPIOID PIPTIDES、SP IN ELECTROACUPUNCTURE |
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| Abstract: | Identified tract cells in lumbar enlargement were recorded from intact ana-esthetized rats.The prolongation of the latency of antidromic action potentialwas a measure of postsynaptic inhibitipn.Both ST 36 and SP 6 were stimulatedelectrically.In EA group (N=12) EA prolonged the latency for 0.111±0.022ms(P<0.001).In bicuculline group (N=12) the prolongation of the latency for0.010±0.004ms (P<0.05) by EA was less than that of EA group with stati-stical significance.In naloxone group (N=12) and SP antiserum group (N=12)EA did not induce a significant prolongation of the latency.It suggested thatGABA,opioides and SP might be involved in postsynaptic inhibition induced byEA. |
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