针刺胃俞、足三里抗急性应激性损害的实验研究

选用 SD 大鼠57只,观察了大鼠正常胃肠里浆膜电极引导的胃电情况,和经束缚-旋转后应激性胃肠里活动的变化。观察到针刺胃俞、足三里能减轻应激性的胃肠粘膜损害。并伴随着对于抑制性胃肠电反应的明显的去抑制作用。

INFLUENCES OF ACUPUNCTURE ON GASTRODUODENAL MUCOSAL LESION AND ELECTRICAL CHANGING INDUCED BY STRESS IN RATS

Experiments were performed in 57 SD rats.The stress was induced by bi-nding plus revolving (5.5xg,170c/min,10min) or cold (0～4℃,30～60min).Selected acupuncture points were “Zusanli” and “Weishu”.Bipolar Ag-AgClrecording electrodes were respectively implanted on the serous membrane surfaceof the antrum,duodenum and on the abdominal skin corresponding to aboveareas.The results were as follows:(1) There are 63.2% individuals in thestress group which showed a large quantity of bleeding points spreading over thegastroduodenal mucosal membrane.The area density of lesion was 15.8～27.7%.Under microscope the signs emerged including mucosal blood vessel dilatationand hyperaemia,gland cell swelling,vi(?)lus broken and peeling off and lymph cellaccumulating,etc.84% individuals showed obvious inhibition of gastroduodenalelectroactivities including that the amplitude of slow wave was lower,the frequ-ency decreased even the rhythm was disordered,the number of fast wave redu-ced and the IDMEC (?) cycle was prolonged.(2)In the group of acupunctureplus stress only 16.7% individuals showed bleeding or hyperaemia,and the lesionarea density was only 1.7%.Also the pathohistological changes were obviouslydecreased.Gastroduodenal electrical changes were hardly seen (27.2%) or theinhibitory state above were significanly reduced (54.5%) when compared withthe stress group.There is strong reason to consider that acupuncture couldeffectively reduce the mucosal lesion and the electrical inhibition of stomachand duodenum induced by stress in rats.