Prostatic adenocarcinoma with marked neuroendocrine differentiation |
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| Authors: | AHM Manjurul Islam Haruaki Kato Masayoshi Hayama Shinya Kobayashi Hiroyoshi Ota Osamu Nishizawa |
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| Affiliation: | Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan. islam@hosp.md.shinshu-u.ac.jp |
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| Abstract: | A case is presented of prostatic cancer with marked neuroendocrine differentiation. Double-labeled immunohistochemical staining was performed with prostate-specific antigen and Chromogranin A. Both antibodies were localized to some of the cancer cells with Paneth cell-like features. Furthermore, most of the cancer cells were positively stained with luminal cell marker CAM 5.2, suggesting that neuroendocrine cells originated from the prostatic luminal cells. |
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| Keywords: | adenocarcinoma carcinoembryonic antigen neuroendocrine cell prostate |
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