| 卵磷脂胆固醇酰基转移酶对实验性高脂血症大鼠血清中高密度脂蛋白胆固醇和游离胆固醇分布的影响 |
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| 引用本文： | 周国英,徐新元,庄庆祺,梅美珍.卵磷脂胆固醇酰基转移酶对实验性高脂血症大鼠血清中高密度脂蛋白胆固醇和游离胆固醇分布的影响[J].复旦学报(医学版),1988(2). |
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| 作者姓名： | 周国英 徐新元 庄庆祺 梅美珍 |
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| 作者单位： | 上海医科大学药学院生物化学教研室，上海医科大学药学院，上海医科大学药学院生物化学教研室，上海医科大学药学院生物化学教研室 1981级毕业生 上海市药品检验所 |
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| 摘 要： | 用纯化的人血清卵磷脂胆固醇酰基转移酶(LCAT)给实验性高脂血症大鼠腹腔注射,发现注射后大鼠血清中高密度脂蛋白胆固醇(HDL-C)水平明显升高,游离胆固醇(FC)水平明显下降,HDL-C/FC和HDL-C/总胆固醇(TC)比值明显升高,FC/TC比值明显下降。对LCAT可能具有防治动脉粥样硬化的作用进行了讨论。
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| 关 键 词： | 总胆固醇 卵磷脂胆固醇酰基转移酶 游离胆固醇 高密度脂蛋白胆固醇 胆固醇酯 |
THE EFFECT OF LECITHIN CHOLESTEROL ACYLTRANSFERASE ON HIGH DENSITY LIPOPROTEIN-CHOLESTEROL AND FREE CHOLESTEROL IN SERUM OF EXPERIMENTAL HYPERLIPIDEMIC RATS |
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| Zhou Guoying,Xu Xinyuan,Zhuang Qingqi,Mei Meizheng.THE EFFECT OF LECITHIN CHOLESTEROL ACYLTRANSFERASE ON HIGH DENSITY LIPOPROTEIN-CHOLESTEROL AND FREE CHOLESTEROL IN SERUM OF EXPERIMENTAL HYPERLIPIDEMIC RATS[J].Fudan University Journal of Medical Sciences,1988(2). |
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| Authors: | Zhou Guoying Xu Xinyuan Zhuang Qingqi Mei Meizheng |
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| Abstract: | We treated experimental hyperlipidemic rats with purified lecithin cholesterol acylbransferase(LOAT) from human serum by abdominal injection. It was found that the high density lipoprotein-cholesterol (HDL-C) level, the ratios of HDL-C/ FC and HDL-C/TC significantly increased, while the FC level and FC/TC ratio significantly decreased.Because HDL-C is an anti-atherosclerotic factor, and LCAT injection could significantly increase the HDL-C level, LCAT might have very important potentiality in the prevention of atherosclerosis and its relative diseases. |
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| Keywords: | total cholesterol lecithin cholesterol acyltransferase free cholesterol high density lipoprotein-cholesterol cholesterolester |
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