正常和便秘模型动物排便实验研究进展

近年来用多种方法成功地在大鼠、家兔、狗与猴等动物体内建立了若干新的便秘动物模型与排便实验方法。本文简要介绍这些模型的制作方法及其在药物研究中的应用:药物性便秘动物模型包括阿米替林所致猕猴便秘模型,吗啡所致家兔便秘模型,溴莫尼定和吗啡所致雪貂弛缓性与痉挛性便秘模型,洛哌丁胺所致大鼠便秘模型及对结肠黏液影响的研究;正常动物排便实验包括正常家兔与狗排便实验及清醒猴胃肠收缩活动测量。这些便秘模型制备方法,将有益于抗便秘药物研究时的选择应用。

Survey of studies on defecation in normal and constipated animal model

In recent years,new methods of defecation experiment in normal and constipated animal model have been successfully established in some species such as rats,rabbits,dogs and cynomolgus monkeys induced by several condition.This paper briefly introduced the progress in preparation of defecation in normal and consti- pated animal models,which was classified into two cate- gories.(1)Drug-induced constipation animal models:ami- triptyline-induced constipation in cynomolgus monkeys, morphine-induced constipated rabbits,brimonidine and morphine-induced atonic or spastic constipated ferrets, and loperamide-induced constipated rats and its colonic mucus decreased.(2)Defecation in normal animal mode- ls,including defecation in normal rabbits and dogs,mea- surement of gastrointestinal contractile activity in con- scious monkeys.The paper reviewed the progress on methodoloyg of constipated animal model which will be useful for the study on the anticonstipation drugs.