| 高密度脂蛋白胆固醇代谢及其对冠心病影响的研究进展 |
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| 引用本文： | 陈国良,刘立伟,谢爽,刘红,刘玉清. 高密度脂蛋白胆固醇代谢及其对冠心病影响的研究进展[J]. 心血管病学进展, 2010, 31(3): 360-363. DOI: 10.3969/j.issn.1004-3934.2010.03.010 |
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| 作者姓名： | 陈国良 刘立伟 谢爽 刘红 刘玉清 |
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| 作者单位： | 北京协和医学院,中国医学科学院,阜外心血管病医院临床药理中心,卫生部心血管药物临床研究重点实验室,北京,100037 |
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| 基金项目： | 国家科技重大专项基金 |
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| 摘 要： | 高密度脂蛋白胆固醇的含量与冠心病的发病成反比;除了胆固醇逆转运外,高密度脂蛋白还通过抗炎、抗氧化、抑制血栓形成和改善内皮细胞功能等多种方式参与抗动脉粥样硬化作用;但在某些情况下,高密度脂蛋白的抗动脉粥样硬化作用也会发生改变甚至会出现促进动脉粥样硬化发展的作用。
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| 关 键 词： | 高密度脂蛋白 动脉粥样硬化 冠心病 |
High-density Lipoprotein Metabolism and Its Influence to Coronary Heart Disease |
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| CHEN Guo-liang,LIU Li-wei,XIE Shuang,LIU Hong,LIU Yu-qing. High-density Lipoprotein Metabolism and Its Influence to Coronary Heart Disease[J]. Advances in Cardiovascular Diseases, 2010, 31(3): 360-363. DOI: 10.3969/j.issn.1004-3934.2010.03.010 |
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| Authors: | CHEN Guo-liang LIU Li-wei XIE Shuang LIU Hong LIU Yu-qing |
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| Affiliation: | CHEN Guo-liang,LIU Li-wei,XIE Shuang,LIU Hong,LIU Yu-qing,LI Yi-shi(Key Laboratory of Clinical Trial Research in Cardiovascular Drug Ministry of Health,Cardiovascular Institute and Fuwai Hospital,Peking Union Medical College and Chinese Academy of Medical Science,Beijing 100037,China) |
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| Abstract: | High-density lipoprotein cholesterol levels are inversely associated with coronary heart disease.Apart from reversal transferring of cholesterol,high-density lipoprotein participate the effect of atherosclrosis by antioxidation,antiinflammation,inhibiting thrombosis and improving endothelial function.However,high-density lipoprotein can become dysfunctional and proatherogenic under certain circumstances. |
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| Keywords: | high-density lipoprotein atherosclerosis coronary heart disease |
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