南虎凝胶剂抗炎镇痛作用的研究

目的:评价南虎凝胶剂的抗炎镇痛作用。方法:用二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足爪肿胀及Ⅱ型胶原诱导的胶原性关节炎模型(CIA),考察南虎凝胶剂的抗炎作用;热板法及CIA大鼠足压痛法,观察南虎凝胶剂的镇痛作用。结果:南虎凝胶剂外用给药,可明显减轻小鼠耳肿胀度,降低角叉菜胶所致大鼠足爪肿胀,减少CIA大鼠四肢炎症积分;CIA大鼠足压痛和热板反应均显示南虎凝胶剂能明显延长大小鼠痛阈值。结论:南虎凝胶剂对急、慢性炎症反应均有明显的抑制作用,对热和炎症刺激引起的疼痛反应有明显的镇痛作用。

Anti-inflammatory and Analgesic Effects of Nanhu Gelata

Objectives:To study the anti-inflammatory and analgesic effects of Nanhu Gelata.Methods: Models of acute inflammatory reactions of xylene-induced mouse ear edema,carrageenam-induced rat paw edema and the chronic inflammatory reaction of collagen-induced arthritis(CIA) in rat were performed to study the anti-inflammatory effects.Models of foot tenderness in CIA rats and hot-plate test in mice were used to study the analgesic effects.Results:Nanhu Gelata significantly suppressed xylene-induced mouse ear edema and carrageenan-induced rat paw edema.The limbs arthritic scores in CIA rats were reduced.The pain threshold of CIA rats foot tenderness and hot-plate test mice were remarkably improved by Nanhu Gelata.Conclusions: Nanhu Gelata manifested obviously anti-inflammatory effects on acute and chronic inflammatory reactions.Nanhu Gelata significantly relieved pain reactions induced by heat and inflammation.