| Changes of Na＋－K＋－ATPase activity and neuronal ultrastructure in cerebral cortex of rats exposed to a 5000m simulated high al |
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| 引用本文： | 王清华,王宪荣,徐如祥.Changes of Na＋－K＋－ATPase activity and neuronal ultrastructure in cerebral cortex of rats exposed to a 5000m simulated high al[J].中国人民解放军军医大学学报,1996(3). |
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| 作者姓名： | 王清华 王宪荣 徐如祥 |
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| 作者单位： | Wang Qinghua1;Wang Xianrong; Xu Ruxiang (1 Department of Neurosurgery，Zhujiang Hospital，First Military Medical University，Guangzhou，510282)(2 Department of Neurosurgery，Southwest Hospital，Third Military Medical University，Chongqing，630038) |
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| 摘 要： | ＣｈａｎｇｅｓｏｆＮａ＋－Ｋ＋－ＡＴＰａｓｅａｃｔｉｖｉｔｙａｎｄｎｅｕｒｏｎａｌｕｌｔｒａｓｔｒｕｃｔｕｒｅｉｎｃｅｒｅｂｒａｌｃｏｒｔｅｘｏｆｒａｔｓｅｘｐｏｓｅｄｔｏａ５０００ｍｓｉｍｕｌａｔｅｄｈｉｇｈａｌｔｉｔｕｄｅＷａｎｇＱｉｎｇｈｕａ１...
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Changes of Na+ -K+ -ATPase activity and neuronal ultrastructure in cerebral cortex of rats exposed to a 5 000 m simulated high altitude |
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| Wang Qinghua,Wang Xianrong, Xu Ruxiang.Changes of Na+ -K+ -ATPase activity and neuronal ultrastructure in cerebral cortex of rats exposed to a 5 000 m simulated high altitude[J].Journal of Medical Colleges of PLA(China),1996(3). |
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| Authors: | Wang Qinghua Wang Xianrong Xu Ruxiang |
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| Institution: | Wang Qinghua1,Wang Xianrong, Xu Ruxiang |
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| Abstract: | A model of high altitude cerebral hypoxia was made by two weeks' exposure to simulated high altitude of 5000 min 48 Wistar rats.The levels of Na+ -K+ -ATPase and Na+,K+ and water contents in the brain cortex were measured. The changes of neuronal ultrastructure were revealed with transmission electron microscope (TEM)examination. The results showed that the activity of Na+ -K+ -ATPase in the cerebral cortex reduced significantly (P<0. 01).The contents of Na+ and water in the cerebral cortex increased evidently (P<0.01).The damage of cortical neurons and neuronal swelling were very obvious under TEM.The experimental findings suggest that the depression of Na+-K+-ATPase activity and metabolic disorders of Na+ and K+ in the brain tissue might be an important factor for the occurrence and development of high altitude cerebral edema. |
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| Keywords: | high altitude Na+-K+-ATPase hypoxia rats |
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