雌二醇诱发大鼠高血压后相关组织中Ca，Cu及Zn含量的变化

①目的探讨雌二醇诱发大鼠血压升高与某些离子的关系。②方法用原子吸收分光光度法（火焰法），检测了雌二醇诱发血压升高组及对照组大鼠血清、延髓、肾上腺、心肌和肾脏组织中Ｃａ２＋，Ｃｕ２＋和Ｚｎ２＋的含量，经ｔ检验统计处理。③结果与对照组相比，实验组大鼠血清和延髓中Ｃａ２＋的含量增加（ｔ＝２．３０３，Ｐ＜０．０５；ｔ＝２．０８５，Ｐ＜０．０５），而肾上腺和心肌中Ｃａ２＋含量减少（ｔ＝３．５１０，Ｐ＜０．０１；ｔ＝２．１０４，Ｐ＜０．０５）。血清和肾脏中Ｃｕ２＋含量增加（ｔ＝２．４５４，Ｐ＜０．０５；ｔ＝２．５６４，Ｐ＜０．０１），而延髓中Ｃｕ２＋含量减少（ｔ＝２．２５４，Ｐ＜０．０５）。延髓和肾上腺Ｚｎ２＋含量增高（ｔ＝２．５０２，Ｐ＜０．０５；ｔ＝２．１４７，Ｐ＜０．０５），而心肌和肾脏Ｚｎ２＋含量减少（ｔ＝２．０７７，Ｐ＜０．０５；ｔ＝２．４９８，Ｐ＜０．０５）。④结论Ｃａ２＋，Ｃｕ２＋和Ｚｎ２＋可能参与雌二醇诱发大鼠高血压

CHANGES OF Ca,Cu,Zn CONTENTS IN RAT TISSUES FOLLOWING HYPERTENSION INDUCED BY HIGH DOSE ESTRADIOL

Objective To study the relationship between Ca,Cu,Zn and rat hypertension induced by Estradiol(E 2).Method The contents of Ca 2+ ,Cu 2+ ,Zn 2+ in serum,medulla oblongata,adrenal gland,cardiac muscle and kidney of rats were measured by atomic absorption spectrophotometer in both hypertension group induced by E 2 and control goup.Results Compared with the control group,in the hypertension group,Ca 2+ level was higher in medulla oblongata and serum (t=2.303,P< 0.05; t=2.085,P<0.05),and lower in adrenal gland and cardiac muscle (t=3.510,P<0.01;t=2.104,P<0.05);the level of Zn 2+ was markedly increased in medulla oblongata and adrenal gland (t= 2.502, P<0.05;t=2.147,P<0.05),decreased in cardiac muscle and kidney (t=2.077,P<0.05;t=2.498,P< 0.05); the content of Cu 2+ was increased in serum and kidney (t=2.454,P<0.05;t=2.564,P<0.01),and decreased in medulla oblongata ( t=2.254,P <0.05).Conclusion Ca 2+ ,Cu 2+ ,Zn 2+ were involved in the process of rat hypertension induced by E 2.