非酒精性脂肪肝与血清瘦素和可溶性瘦素受体的关系

目的探讨非酒精性脂肪肝(NAFLD) 发病与患者血清瘦素、可溶性瘦素受体、体重指数(BMI) 及血脂紊乱的关系。方法对96 例经肝穿活检诊断为NAFLD 的患者分为轻、中、重三度, 同时选择20 例肝穿活检正常者为对照, 检测血清瘦素、可溶性瘦素受体水平、空腹血糖、血脂, 测量身高、体质量, 计算BMI。结果NAFLD 组与对照组之间血清瘦素水平、可溶性瘦素受体水平、BMI 及血脂紊乱比较有显著差异( P<0.05 或0.01) 。NAFLD 患者随病变程度加重, 血清瘦素水平有逐渐增高的趋势, 且呈正相关关系(p<0.05)，而可溶性瘦素受体水平逐步下降，呈负相关关系(p<0.05)。结论血清瘦素、可溶性瘦素受体、BMI 增高及血脂紊乱是NAFLD 发病的危险因素, NAFLD 病变程度与血清瘦素水平呈正相关，与可溶性瘦素受体水平呈负相关。

Association of serum leptin and soluble leptin receptor with nonalcoholic fatty liver disease

Objective To investigate the relationship among serum leptin, soluble leptin receptor , body mass index (BMI) and dyslipidema in patients with nonalcoholic fatty liver disease (NAFLD). Methods:ninty six patients with NAFLD were divided into mild, moderate and severe NAFLD groups according histological examination results of the liver. Twenty healthy volunteers were chosen as the normal contro1 (NC) group. Leptin, soluble leptin receptor , glucose and lipid levels were measured in the 96 patients with NAFLD and the BMI calculated. Results: Leptin, soluble leptin receptor, BMI and dyslipidemia showed significant differences between NAFLD and NC groups (P<0.05 or 0.01). Leptin index increased with the exacerbation of NAFLD, was positively correlated with the severity of NAFLD(p<0.05),and soluble leptin receptor index decreased , was negatively correlated with the severity of NAFLD(p<0.05).Conclusion :Leptin , soluble leptin receptor,BMI and dyslipidemia can be important risk factors of NAFLD.Serum leptin level is positively correlatedwith the severity of NAFLD,and Soluble leptin receptor level is negatively correlated .